The Tuberous Sclerosis Alliance launched a web-based TSC Natural History Database in Fall 2006 to collect and store medical information about individuals with tuberous sclerosis complex over their lifetimes. This information-collecting effort is being conducted through a network of participating TSC Clinics nationwide. For more information contact the Tuberous Sclerosis Alliance at (800) 225-6872 or email firstname.lastname@example.org.
The Brain and Tissue Bank for Developmental Disorders at the University of Maryland (BTBUMAB), which is under contract with the National Institute of Child Health and Human Development at the National Institutes of Health, collects, stores and distributes human brain and other tissues for research. For more information, go to their website or contact the Tuberous Sclerosis Alliance at (800) 225-6872 or email email@example.com.
TSC1 knockout mice developed and characterized in the David Kwiatkowski, M.D., Ph.D. laboratory at Brigham & Women's University in Boston are now available through the shared National Cancer Institute animal facility in Frederick, Maryland.
For more information and to obtain animals contact:
Mary Ann Sandeen
MMHCC (Mouse Model Human Cancer Consortium) c/o Receiving and Quarantine Facility NCI-Frederick
Bldg 429 Miller Dr.
Frederick, MD 21702
The TSC2 knockout mice have been transferred from David Kwiatkowski's laboratory at the Brigham & Women's Hospital to The Jackson Laboratory. A description of the new strains under development process and associated time requirements are described in "Frequently Asked Questions" at http://jaxmice.jax.org/support/faq/index.html.
Investigators who are interested in obtaining this strain should register their interest on The Jackson Laboratory Strains Under Development web page. This will ensure that they receive advance notification of pending availability. The URL for the strain Data Sheet with a link to register interest is: http://jaxmice.jax.org/micedata.shtml?004686.
If you have any questions contact:
Phyllis A. Mobraaten
GEMMS Product Coordinator JAX Research Systems/IMR
The Jackson Laboratory
610 Main Street
Bar Harbor, ME 04609
The TS Alliance has supported the development of comprehensive TSC1 and TSC2 variation databases. These databases are curated by Professor Sue Povey and Dr. Rosemary Ekong at University College London. Researchers and clinicians, as well as the genetic testing laboratories, will be interested in these databases containing all of the known variations (mutations and polymorphisms) in the TSC genes that will be regularly updated and revised as new variations are reported. The TSC1/2 Variation Databases can be accessed at:
TSC1 Variation Database
TSC2 Variation Database